Genetic sequencing could help match patients with biomarker-driven cancer...
As cancer researchers continue to identify genetic mutations driving different cancer subtypes, they are also creating a catalog of possible targets for new treatments.
View ArticleAutism may be linked to abnormal immune system characteristics and novel...
Immune system abnormalities that mimic those seen with autism spectrum disorders have been linked to the amyloid precursor protein (APP), reports a research team from the University of South Florida's...
View ArticleFrench breast implant maker denounces 'untruths' in scandal
The founder of the French breast implant maker at the centre of a global health scare said Thursday much of the information emerging in the scandal was untrue but refused further comment.
View ArticleCell-CT: A new dimension in breast cancer research
Despite advances in both the diagnosis and treatment of breast cancer, the disease remains a leading worldwide health concern.
View ArticlePatterns of chromosome abnormality: The key to cancer?
A healthy genome is characterized by 23 pairs of chromosomes, and even a small change in this structure such as an extra copy of a single chromosome can lead to severe physical impairment. So it's...
View ArticleChildren exposed to the common pollutant naphthalene show signs of...
According to a new study, children exposed to high levels of the common air pollutant naphthalene are at increased risk for chromosomal aberrations (CAs), which have been previously associated with...
View ArticleBaby's genome deciphered prenatally from parents' lab tests
Scientists have successfully sequenced the genome of a baby in the womb without tapping its protective fluid sac. This non-invasive approach to obtaining the fetal genome is reported in the June 6...
View ArticleGene mutation can allow proteins to gather, spark tumor growth
Prostate cancer is generally treated as if it's a single disease. But researchers have discovered a new type of the cancer that appears to affect 15 percent of patients, a finding that paves the way...
View ArticleTwo gene mutations drive adrenal cancer
Two different genetic mutations cooperate to induce adrenal cancer, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center and University of Sao Paulo in...
View ArticlePatients with aberrations in two genes respond better to drugs blocking a...
Cancer patients with mutations or variations in two genes -– PIK3CA and PTEN -– who have failed to respond to several, standard treatments, respond significantly better to anti-cancer drugs that...
View ArticleNovel test identifies patients most likely to benefit from ALK inhibition...
Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for...
View ArticleFusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
View ArticleAnalysis of social media use could give therapists more complete view of...
Facebook activity provided a window into the psychological health of participants in a study at the University of Missouri. Social media profiles could eventually be used as tools for psychologists and...
View ArticleA new mechanism that contributes to the evolution of cancer
Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this...
View ArticleNew computational pipeline analyzes tumor images, may help predict response...
(Medical Xpress)—How's this for big data: A whole-slide image of a tumor section can be ten billion pixels. There can be thousands of such images in the tumor cohorts maintained by The Cancer Genome...
View ArticleThe CORE of the matter: Identifying recurrent genomic regions to determine...
(Medical Xpress)—Analyzing genome-wide data from organisms, tissues or cells generates lists of genomic intervals – continuous structures on a genomic sequence, such as a chromosome. An interval's...
View ArticleNew findings validate the accuracy of autism diagnosis in children with Down...
New findings from a 16-year study confirm that the Diagnostic and Statistic Manual of Mental Disorders (DSM), the gold-standard for the classification of mental health conditions, can be used to...
View ArticleIntratumor heterogeneity seen in renal carcinomas
(HealthDay) -- Extensive intratumor heterogeneity, seen in samples obtained from renal carcinomas, may lead to underestimation of the tumor genomics based on single tumor-biopsy samples, according to a...
View ArticleTargeting microRNA may benefit some ovarian and breast cancer patients
A genetic misfire called the 3q26.2 amplicon can cause real havoc. In fact, it is among the most frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.
View ArticleIntratumor morphological heterogeneity of cancer is not related to chromosome...
Intratumor morphological heterogeneity (diversity) of breast cancer is not related to chromosome aberrations. This conclusion was made based on a study by researchers from Tomsk State University (TSU),...
View ArticleLoss of chromosome 8p governs tumor suppression and drug response
In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to...
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